Abstract Objective: To describe the challenges and perspectives of the automation of pain assessment in the Neonatal Intensive Care Unit. Data sources: A search for scientific articles published in the last 10 years on automated neonatal pain assessment was conducted in the main Databases of the Health Area and Engineering Journal Portals, using the descriptors: Pain Measurement, Newborn, Artificial Intelligence, Computer Systems, Software, Automated Facial Recognition. Summary of findings: Fifteen articles were selected and allowed a broad reflection on first, the literature search did not return the various automatic methods that exist to date, and those that exist are not effective enough to replace the human eye; second, computational methods are not yet able to automatically detect pain on partially covered faces and need to be tested during the natural movement of the neonate and with different light intensities; third, for research to advance in this area, databases are needed with more neonatal facial images available for the study of computational methods. Conclusion: There is still a gap between computational methods developed for automated neonatal pain assessment and a practical application that can be used at the bedside in real-time, that is sensitive, specific, and with good accuracy. The studies reviewed described limitations that could be minimized with the development of a tool that identifies pain by analyzing only free facial regions, and the creation and feasibility of a synthetic database of neonatal facial images that is freely available to researchers.

Supervised statistical learning covers important models like Support Vector Machines (SVM) and Linear Discriminant Analysis (LDA). In this paper we describe the idea of using the discriminant weights given by SVM and LDA separating hyperplanes to select the most discriminant features to separate sample groups. Our method, called here as Discriminant Feature Analysis (DFA), is not restricted to any particular probability density function and the number of meaningful discriminant features is not limited to the number of groups. To evaluate the discriminant features selected, two case studies have been investigated using face images and breast lesion data sets. In both case studies, our experimental results show that the DFA approach provides an intuitive interpretation of the differences between the groups, highlighting and reconstructing the most important statistical changes between the sample groups analyzed.